Cholinergic stimulation of vascular prostacyclin synthesis
نویسندگان
چکیده
منابع مشابه
Inhibition of Vascular Endothelial Cell Prostacyclin Synthesis
Vascular endothelial cells (EC) play an active role in the synthesis and assembly of components of the fibrinolytic system and the generation of the major fibrinolytic protease plasmin. However, the reciprocal effects of plasmin on EC function have not been previously examined. We have studied the actions of plasmin on the production of prostacyclin (PGI2) by cultured human umbilical vein (HUVE...
متن کاملInteraction of vasopressin and angiotensin II in stimulation of prostacyclin synthesis in vascular smooth muscle cells.
The effect of angiotensin II (ANG II) and arginine vasopressin (AVP) on prostacyclin production by vascular smooth muscle cells (VSMC) has been examined. Cultured rat aortic VSMC were studied during either static incubation in multiwell plates or during dynamic incubation in superfusion columns. Prostacyclin synthesis was assessed by radioimmunoassaying one of its stable metabolites, 6-keto-pro...
متن کاملStimulation of prostacyclin synthesis in vascular cells by mononuclear cell products.
Supernatants were obtained from human peripheral blood mononuclear cells stimulated with phytohemagglutinin or in a mixed lymphocyte reaction. The effect of mononuclear cell products on vascular prostacyclin (PGI2) production was measured using cultured rat aortic smooth muscle cells (SMC) or aortic rings. PGI2 was measured by radioimmunoassay of its metabolite, 6-keto-PGF1 alpha. Supernatants ...
متن کاملStimulation of human endothelial cell prostacyclin synthesis by select leukotrienes
Cultured endothelial cells from human umbilical cord labeled with [3H]20:4 release radiolabel when exposed to leukotrienes C or D (LTC or LTD). The major radiolabeled 20:4 metabolite recovered in the culture medium was prostacyclin. Both leukotrienes produced a dose-dependent synthesis of prostacyclin, with a maximal response at 10(-7) M leukotriene. LTC promoted a twofold greater response than...
متن کاملInhibition of vascular endothelial cell prostacyclin synthesis by plasmin.
Vascular endothelial cells (EC) play an active role in the synthesis and assembly of components of the fibrinolytic system and the generation of the major fibrinolytic protease plasmin. However, the reciprocal effects of plasmin on EC function have not been previously examined. We have studied the actions of plasmin on the production of prostacyclin (PGI2) by cultured human umbilical vein (HUVE...
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ژورنال
عنوان ژورنال: Prostaglandins
سال: 1983
ISSN: 0090-6980
DOI: 10.1016/0090-6980(83)90191-0